ETIOPATHOGENESIS
Parkinsonism may result from mutation
of several different genes. In idiopathic parkinsonism, dopamine
depletion due to degeneration of dopaminergic nigrostriatal
system leads to imbalance of dopamine and acetylcholine, which
are neurotransmitters normally present in corpus striatum[part
of basal ganglia in cerebrum].
The most regularly observed changes have been in the aggregates
of melanin – containing nerve cells in the brainstem
[substanstia nigra, locus coeruleus], where there are varying
degrees of nerve cell loss with reactive gliosis along with
distinctive eosiophilic intracytoplasmic inclusions.
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